Elacridar hydrochloride
CAS No. 143851-98-3
Elacridar hydrochloride ( GF-120918A )
Catalog No. M11860 CAS No. 143851-98-3
A potent inhibitor of multidrug resistance (MDR) that fully reverses multidrug resistance CHRC5, OV1/DXR and MCF7/ADR cells to the cytotoxicity of doxorubicin and vincristine with IC50 of 0.02 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
50MG | 292 | Get Quote |
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100MG | Get Quote | Get Quote |
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200MG | Get Quote | Get Quote |
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500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameElacridar hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionA potent inhibitor of multidrug resistance (MDR) that fully reverses multidrug resistance CHRC5, OV1/DXR and MCF7/ADR cells to the cytotoxicity of doxorubicin and vincristine with IC50 of 0.02 uM.
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DescriptionA potent inhibitor of multidrug resistance (MDR) that fully reverses multidrug resistance CHRC5, OV1/DXR and MCF7/ADR cells to the cytotoxicity of doxorubicin and vincristine with IC50 of 0.02 uM; effectively competes with [3H]azidopine for binding P-glycoprotein; restores sensitivity of the tumor to a single dose of doxorubicin in mice; orally bioavailable.Breast CancervPhase 1 Discontinued
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SynonymsGF-120918A
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PathwayMembrane Transporter/Ion Channel
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TargetP-glycoprotein
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RecptorP-glycoprotein
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Research AreaCancer
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IndicationBreast Cancer
Chemical Information
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CAS Number143851-98-3
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Formula Weight600.10
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Molecular FormulaC34H34ClN3O5
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCOC1=CC=CC2=C1NC3=C(C2=O)C=CC=C3C(=O)NC4=CC=C(C=C4)CCN5CCC6=CC(=C(C=C6C5)OC)OC.Cl
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Chemical Name4-Acridinecarboxamide, N-[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-, hydrochloride (1:1)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hyafil F, et al. Cancer Res. 1993 Oct 1;53(19):4595-602.
2. den Ouden D, et al. Leukemia. 1996 Dec;10(12):1930-6.
3. Witherspoon SM, et al. Clin Cancer Res. 1996 Jan;2(1):7-12.
2. den Ouden D, et al. Leukemia. 1996 Dec;10(12):1930-6.
3. Witherspoon SM, et al. Clin Cancer Res. 1996 Jan;2(1):7-12.
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